RESEARCH ARTICLE ON NANOGEL AS TOPICAL PROMISING DRUG DELIVERY FOR PSORIASIS

Abstract

Background: Transdermal medication administration seems promising, but it is a difficult method to implement for both local and systemic drug effects.

Objective: The goal of this study was to create a nanogel with a smaller particle size in order to increase the bioavailability of Curcumin, an anti-inflammatory and anti- psoriasis medication.

Methods:The goal of this research is to create nanosize Curcumin dispersion using an emulsion-solvent diffusion technique with the addition of a gelling agent to create a nanogel. Particle sizes in the formulation range from 100 to 400 nanometers. Curcumin is a medication that is used to treat psoriasis and chronic inflammatory disorders.

Results: The glycerol:waterco-solvent system was chosen for the preparation of curcumin nanogels with various polymers because it has a higher permeability coefficient than the alcohol:water co-solvent system. In a franz diffusion cell, permeation across cellophane membrane was achieved using 0.9 percent w/v sodium chloride as the receptor fluid. Curcumin-containing gels with eudragit polymer had a higher permeability coefficient.

Conclusion: In compared to nanogels made with HPMC and methyl cellulose, curcumin nanogels produced with carbopol with permeation enhancer showed greater flux improvement. Curcumin nanogels with carbopol 940 as a gelling agent and Eudragit S-100 as a permeation enhancer.