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The first nanoscale drug to be approved for clinical use in 1995 was known as a liposome. Since then, the technology has grown substantially, and current work on liposome drug delivery systems has revoluted remarkable developments with significant clinical implications. Liposomal drug delivery includes long-circulating liposomes, stealth liposomes, nebulized liposomes, and elastic liposomes for topical, oral, and transdermal delivery, and covalent lipid-drug complexes for improved drug plasma membrane crossing and targeting to specific organelles and other recent advancements. This review is based on the liposomal drug delivery system, its introduction, classification, methods of preparation, types of targeting the liposomal drug delivery, applications, recent advancements in liposomes, and its application.
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