http://ijper.in/index.php/IJPER <p><strong>International Journal of Pharmaceutical Education and Research</strong> (IJPER) is an international, peer-reviewed, open access journal devoted to various segments of pharmaceutical sciences. It’s a biannually published journal that publishes quality manuscripts (original research, reviews, short communications, mini-reviews and case reports) relevant to the various fields of Pharmaceutical Sciences.&nbsp;</p> <table border="1" cellspacing="0" cellpadding="5"> <tbody> <tr> <td valign="top" width="265"> <div align="center"><strong>&nbsp;</strong><strong>Starting Year</strong><br>2019</div> </td> <td valign="top" width="301"> <div align="center"><strong>Journal ISSN<br></strong>2582-2152 (Online)</div> </td> <td valign="top" width="234"> <div align="center"><strong>CrossRef DOI Prefix</strong><br>10.37021</div> </td> <td valign="top" width="218"> <div align="center"><strong>Frequency</strong><br>2 Issues/Year (Biannual)</div> </td> </tr> <tr> <td valign="top"> <div align="center"><strong>&nbsp;</strong><strong>Publishing System</strong></div> <div align="center">Open Journal System<strong><br> </strong> (OJS) by Public knowledge Project (PKP)</div> </td> <td valign="top"> <div align="center"><strong>Copyright License Type</strong></div> <div align="center">Creative Common Attribution-NonCommercial 4.0 International<br>(CC BY-NC-SA 4.0)</div> </td> <td valign="top"> <div align="center"><strong>Email</strong></div> <div class="style1" align="center">ijper.editor@gmail.com</div> <div class="style1" align="center">editor@ijper.in</div> </td> <td valign="top"> <div align="center"><strong>Primary Contact</strong></div> <div align="center">+91-7974318397</div> </td> </tr> </tbody> </table> <p>&nbsp;</p> <p><strong>Journal Abbreviation:</strong>&nbsp; <em>Int. J. Pharm. Edu. Res.</em></p> <p><strong>Indexing:</strong>&nbsp; International Journal of Pharmaceutical Education and Research, IJPER is indexed with <a href="https://scholar.google.co.in/citations?user=CEhnT44AAAAJ&amp;hl=en">Google Scholar</a>, <a href="https://www.researchgate.net/journal/2582-2152_INTERNATIONAL_JOURNAL_OF_PHARMACEUTICAL_EDUCATION_AND_RESEARCH_IJPER">ResearchGate,</a> World Cat, <a href="https://cassi.cas.org/publication.jsp?P=DXaT8ZV7yNcyz133K_ll3zLPXfcr-WXfNKTEt1-l894yz133K_ll3zLPXfcr-WXf-9sRQmIIxJMyz133K_ll3zLPXfcr-WXfIY0JLEXX41RsDpuJibhy6A">CAS Source Index (CASSI)</a>,&nbsp;<a href="https://portal.issn.org/resource/ISSN/2582-2152#">ROAD (Directory of Open Access Scholarly Resources)</a>,&nbsp;<a href="http://journalseeker.researchbib.com/?action=viewJournalseekerSearch">Research Bible (Academic Resource Index)</a>, <a href="https://www.sciencegate.app/source/401708839">SCIENCEGATE</a>,&nbsp;<a href="http://olddrji.lbp.world/JournalProfile.aspx?jid=2582-2152">Directory of Research Journals Indexing (DRJI)</a>,&nbsp; Index Copernicus (ICV),&nbsp;Crossref,&nbsp;and many more.</p> <p><strong>Why IJPER?</strong></p> <ul> <li class="show">Global audience with Open and immediate access to all publications.</li> <li class="show">Worldwide dissemination through OJS platform.</li> <li class="show">Prompt and unbiased review process.</li> <li class="show">Indexed with the most important international bibliographic databases.</li> <li class="show">Regular alerts on E-mail</li> </ul> <p><strong>Articles invited for Volume 6, Issue 2.</strong></p> Ram-Eesh Institute of Vocational and Technical Education en-US INTERNATIONAL JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH (IJPER) 2582-2152 http://ijper.in/index.php/IJPER/article/view/246 Shilajit, a complex herbo-mineral extract, has played a vital role in traditional medicine, particularlyin Ayurveda, for centuries. This sticky, tar-like substance, predominantly found in the Himalayan region, is composed of a rich mixture of humic substances, essential minerals, and various bioactive compounds. Traditionally, it has been used to treat a wide range of health conditions, including genitourinary issues, diabetes, respiratory ailments, and cognitive disorders. Recent preclinical studies have highlighted the potential benefits of Shilajit in enhancing the energy metabolism and androgenic health. Shilajit has shown promise in improving sperm quality, increasing testosterone levels, and mitigating chronic fatigue, through its antioxidant and adaptogenic properties. These results are further supported by clinical research, which shows that Shilajit supplements significantly improve testosterone levels and male infertility parameters. Safety assessments revealed a generally favorable profile, with no severe adverse effects reported in acute and chronic toxicity studies. This review draws on an extensive range of literature sources, including Google Scholar, PubMed, Research Gate, and Science Direct, to provide a detailed synthesis of the therapeutic potential and safety of Shilajit. Despite its extensive use in traditional practice, there is a need for more rigorous research to fully understand the mechanisms of action of Shilajitand validate its efficacy in modern medicine. This comprehensive review underscores the importance of continued research to bridge traditional knowledge with contemporary scientific validation, potentially integrating Shilajit into mainstream healthcare practices. HN Shivaprasad Sravani T Tharun M Madhu Krishnamani Gaurav soni ##submission.copyrightStatement## 2024-12-19 2024-12-19 6 02 26 31 10.37021/ijper.v6i2.03 http://ijper.in/index.php/IJPER/article/view/270 Diabetes is a metabolic illness that affect millions of people worldwide. The current therapy used in the treatment of diabetes leads to various adverse effect such as improper dosing schedule, low potency, ineffective targeting, reduced metabolism and weight gain. Therefore, there is the great need of antidiabetic drugs which helps to reduce the suffering of patients. Dipeptidyl peptidase 4 (DPP-4) has emerged as highly a powerful therapeutic treatment option for the management of type-2 diabetes mellitus (T2DM). The DPP-4 inhibitors works at a molecular level by blocking the enzymatic activity of DPP-4 that increases the half-life of endogenous incretin hormones that includes glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This leads to enhanced glucose-dependent insulin secretion, suppression of glucagon secretion, delayed gastric emptying and ultimately improved glycemic control. In clinical trials, DPP-4 inhibitors have demonstrated efficacy as monotherapy or in combination with other anti-diabetic drugs, like metformin, sulfonylureas etc. Various clinical trials have highlighted their ability to reduce hemoglobinA1c (HbA1c) level, fasting plasma glucose and post-prandial hyperglycaemic excursions, they also give benefits on weight neutrality and low risk of hypoglyceamia. This review provides a comprehensive overview of the molecular mechanisms and clinical implications of DPP-4 inhibitors in diabetes management. In addition, DPP-4 inhibitors represent a valuable therapeutic option for the management of T2DM. Leesha Varshney Payal Kesharwani Anupam . Pallavi Manish Lavhalle ##submission.copyrightStatement## 2024-12-13 2024-12-13 6 02 12 25 10.37021/ijper.v6i2.02 http://ijper.in/index.php/IJPER/article/view/245 Triple-negative breast cancer (TNBC) is a highly aggressive and heterogeneous subtype of breast cancer, characterized by the lack of estrogen, progesterone, and HER2 receptors, accounting for 15% of all breast cancer cases, with a higher prevalence in premenopausal African and African American women. Despite advances in treatment options, TNBC remains a significant clinical challenge due to its poor prognosis, high recurrence rate, and limited targeted therapies. This review highlights the current understanding of TNBC’s molecular landscape, clinical features, and treatment strategies, including chemotherapy, immunotherapy, and emerging targeted agents. However, further research is needed to unravel the complexities of TNBC and develop effective personalized treatment approaches to improve patient outcomes. The lack of effective targeted therapies and high recurrence rates emphasize the need for continued research into the molecular mechanisms driving TNBC, as well as the development of novel therapeutic strategies. By advancing our understanding of TNBC’s biology and identifying new targets for therapy, we can hope to improve treatment options and outcomes for patients with this devastating disease. Ultimately, a multidisciplinary approach, combining basic science, clinical research, and patient care, is necessary to make meaningful progress against TNBC and improve the lives of those affected by this disease. Sanjana Kumari Vikas Sharma ##submission.copyrightStatement## 2024-12-11 2024-12-11 6 02 1 11 10.37021/ijper.v6i2.01 http://ijper.in/index.php/IJPER/article/view/272 Ajwain is an annual tropical aromatic herb widely known as Trachyspermum ammi (Apiaceae) also it is an annual plant which is widely cultivated in India, Iran and Persia. The fruits of T. ammi (Ajwain) traditionally were used as diuretic, carminative, and anthelmintic. Ajwain has been found to have numerous biological effects, including antibacterial, antiviral, antifungal, and antioxidant properties. Evaluating the antibacterial activity of hexane extract of seeds and essential oil against Escherichia coli bacterial strains was the purpose of this present research. After the preparation of the extracts and essential oil, the growth inhibitory zone assay was used to evaluate the antibacterial activity utilizing the disc diffusion, weight variation, and colony counting methods. Minimum inhibitory concentration (MIC) was measured by comparing results of growth inhibitory zone assay. The Amoxicillin stock solution (1 mg/ml) for zone of inhibition served as the benchmark for the comparative evaluation. The different outcome data was examined and results were compared among each other. After conducting a thorough analysis, we have determined that ajwain essential oil exhibits greater antibacterial activity as compared to ajwain seed extract. Mayank Chaudhary Nishant Kumar Pallavi M. Lavhale Gaurav Upadhyay ##submission.copyrightStatement## 2024-12-13 2024-12-13 6 02 32 36 10.37021/ijper.v6i2.04