Formulation & Evaluation of a Microsphere Loaded Topical Gel for Acne vulgaris containing Benzoyl Peroxide

Abstract

Benzoyl peroxide (BPO) is a first-line topical treatment in acne vulgaris. It is commonly used in topical formulations for the treatment of acne and athletes foot. Skin irritation is a common side effect, and it has been shown that controlled release of BPO from a delivery system to the skin could reduce the side effect while reducing percutaneous absorption. Therefore, the aim of the present study was to produce Eudragit L 100 microparticles containing BPO which were able to control the release of BPO to the skin. Microspheres were prepared by Solvent Evaporation Technique. Microspheres are optimized on the basis of their properties like Entrapment efficiency, % drug loading, % yield & Particle size. Polymers Ethyl cellulose, Eudragit L100, Eudragit RS 100 were used in the formulations of Microspheres & the optimized batch incorporate in Gel preparation.