POLYMERIC NANOPARTICLES: AN OVERVIEW OF PREPARATION, CHARACTERIZATION, APPLICATIONS, AND FUTURE PERSPECTIVES

Abstract

Polymeric nanoparticles (NPs) are tiny particles with a size between 10 and 1000 nm, with the ability to contain or have active substances surface-adsorbed onto the polymeric core. Both nanospheres and nano capsules are under the umbrella of "nanoparticles," which are distinguished by the morphological organisation. For the targeted delivery of medications used to treat a variety of disorders, polymeric NPs have demonstrated considerable promise. We go through the most popular techniques for creating and characterising polymeric NPs, the effectiveness of the active ingredient's connection with the polymeric core, and in vitro release mechanisms in this review. Due to their adaptability and broad range of features, polymeric nanoparticles have recently gained more potential usage as carriers for a variety of pharmaceuticals in therapeutic applications. Due to the drawbacks of conventional pharmacological therapy, there will be a higher risk of unpleasant responses. These days, nanoparticles are becoming more and more significant since they enable activity at specific locations. These nanoparticles enable the precise targeting of different cells or receptors. Cellular absorption and internalisation are both regulated in a number of different ways.