An Observational Overview Regarding ADRs of Antihypertensive Drugs Used in Tertiary Care Hospitals

Abstract

Introduction: The analysis and control of antihypertensive
drugs concerning ADRs were studied in tertiary care
hospitals. It helps determine a drug’s safety, efficacy, and
appropriateness. The monitoring of adverse drug reactions
(ADRs) involves tracking their occurrence and classifying them
as types A to F. Two systems that support ADR reporting are
EudraVigilance and MedWatch.
Materials and methods: Involving 131 patients this study
examined the use of antihypertensive medications in treating
hypertension as well as the monitoring of adverse drug
reactions (ADRs). Patient profiles and physician records were
two of the data sources. The study was conducted through a
questionnaire-based Google Form and an informed consent
document.
Result and discussion: 68.8% males are affected which
is far more as compared to females which are 31.2% from
hypertension disease. 71.9% of the patients were on mono
therapy as compared to double and multiple therapy for
the treatment of hypertension disease. And 90.6% patients
consume tablets as a dosage form which makes it the preferred
choice among the patients.
Conclusion: The results revealed a preference for allopathic
medications, monotherapy over combination therapies, and
the use of calcium channel blockers (Amlodipine) and ARB
blockers (Losartan, Telmisartan).The ADR registered for ARB
blockers (Losartan, Telmisartan) are UTI Infection, Dyspnoea,
Dyspepsia, fainting and reduction in kidney output.